Kaliuzhin V V, Tepliakov A T, Maleeva M A, Pushnikova E Iu, Solovtsov M A
Ter Arkh. 2000;72(9):44-7.
To study a relationship between reduced heart rate variability and ventricular ectopic activity in patients with coronary artery disease and also efficiency of atenolol in suppression of ventricular arrhythmias and increase of heart rate variability.
32 men with stable angina of effort (functional class II-III) after the first myocardial infarction (mean age 52.9 years). 24-h ECG monitoring was carried out in 25 patients before and 3 weeks after treatment with atenolol in the dose 50-100 mg/day for 3 weeks.
The mean standard deviation of the R-R intervals in 24 hours was much lower in patients with ventricular arrhythmias. In the majority of the patients with frequent ventricular premature beats (> 10 VPB/hour), the changes in vegetative homeostasis manifested mainly by activation of sympathetic nervous system. Atenolol given for 3 weeks to these patients proved effective.
Low heart rate variability correlated with increased frequency of ventricular premature beats. Atenolol can be recommended for the treatment of such patients.
研究冠心病患者心率变异性降低与室性异位活动之间的关系，以及阿替洛尔抑制室性心律失常和增加心率变异性的效果。
32名首次心肌梗死后患有稳定劳力性心绞痛（心功能II - III级）的男性患者（平均年龄52.9岁）。25名患者在接受剂量为50 - 100毫克/天的阿替洛尔治疗3周前和治疗3周后进行了24小时心电图监测。
室性心律失常患者24小时R - R间期的平均标准差低得多。在大多数频发室性早搏（>10次室性早搏/小时）的患者中，自主神经平衡的变化主要表现为交感神经系统激活。给这些患者服用阿替洛尔3周证明是有效的。
低心率变异性与室性早搏频率增加相关。阿替洛尔可推荐用于此类患者的治疗。
