Blanas N, Freund B, Schwartz M, Furst I M
University of Toronto, Cambridge Memorial Hospital, Canada.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov;90(5):553-8. doi: 10.1067/moe.2000.110814.
To clarify the natural history of the odontogenic keratocyst (OKC) and to evaluate treatments with respect to the likelihood of recurrence.
A systematic review of the literature was completed pertaining to the treatment and prognosis of the OKC. Each investigation was evaluated based on 4 inclusion criteria. Each study that met the 4 inclusion criteria was then evaluated based on 8 standards.
Of 2290 citations reviewed pertaining to the OKC, 14 investigations were found to meet the 4 inclusion criteria. Resection was found to have the lowest recurrence rate (0%) but the highest morbidity rate. Simple enucleation was reported to have a recurrence rate of 17% to 56%. Simple enucleation combined with adjunctive therapy, such as the application of Carnoy's solution or decompression before enucleation, was reported to have recurrence rates of 1% to 8.7%.
Although the existing literature consists of retrospective consecutive case series, it appears that resection or enucleation with adjunctive therapy is associated with recurrence rates that are lower than those associated with enucleation alone.
阐明牙源性角化囊肿（OKC）的自然病史，并评估各种治疗方法的复发可能性。
完成了一项关于OKC治疗与预后的文献系统综述。每项研究根据4项纳入标准进行评估。然后，对每项符合这4项纳入标准的研究依据8条标准进行评估。
在检索到的2290篇与OKC相关的文献中，发现有14项研究符合4项纳入标准。结果显示，切除术的复发率最低（0%），但发病率最高。单纯摘除术的复发率据报道为17%至56%。单纯摘除术联合辅助治疗，如应用卡诺氏液或摘除术前减压，据报道复发率为1%至8.7%。
尽管现有文献均为回顾性连续病例系列研究，但似乎切除术或联合辅助治疗的摘除术的复发率低于单纯摘除术。
