Sen B H, Akdeniz B G, Denizci A A
Department of Restorative Dentistry and Endodontology, Ege University, Izmir, Turkey.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov;90(5):651-5. doi: 10.1067/moe.2000.109640.
The aim of this study was to evaluate the antifungal effect of ethylenediamine-tetraacetic acid (EDTA) on Candida albicans, comparing it with that of various disinfectants and common antifungal agents.
Two clinical oral isolates and 1 standard strain of C albicans were included in this study. Main contents of the test solutions were sodium hypochlorite, EDTA, chlorhexidine, hexetidine, benzalkonium chloride, povidone-iodine, nystatin, and ketoconazole. The agar diffusion method was used to determine the antifungal effects of the solutions. Zones of inhibition were recorded and the results were analyzed statistically by using a 2-way analysis of variance.
EDTA demonstrated the highest antifungal activity in comparison with routine antifungal drugs and all other solutions (P <.0001). Oral cavity isolate was more resistant to the test solutions (P <.0001).
The selection of irrigating and disinfecting solution in root canals of patients with a particularly high incidence of oral candidiasis gains extreme importance. EDTA may be strongly recommended during endodontic therapy of these patients.
本研究旨在评估乙二胺四乙酸（EDTA）对白色念珠菌的抗真菌作用，并将其与各种消毒剂和常见抗真菌剂进行比较。
本研究纳入了2株临床口腔分离株和1株白色念珠菌标准菌株。测试溶液的主要成分有次氯酸钠、EDTA、氯己定、己脒定、苯扎氯铵、聚维酮碘、制霉菌素和酮康唑。采用琼脂扩散法测定溶液的抗真菌作用。记录抑菌圈，并使用双向方差分析对结果进行统计学分析。
与常规抗真菌药物和所有其他溶液相比，EDTA表现出最高的抗真菌活性（P<.0001）。口腔分离株对测试溶液的耐药性更强（P<.0001）。
在口腔念珠菌病发病率特别高的患者的根管中，冲洗和消毒溶液的选择变得极其重要。在这些患者的根管治疗期间，强烈推荐使用EDTA。
