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[全腔静脉肺动脉吻合术后晚期心律失常及其与手术时患者年龄的相关性]

[Late postoperative cardiac arrhythmias after total cavopulmonary anastomosis and correlation with age of the patients at operation].

作者信息

Hofbeck M, Koch A, Buheitel G, Gerling S, Rauch R, Weyand M, Singer H

机构信息

Univ. Kinderklinik Erlangen.

出版信息

Z Kardiol. 2000 Sep;89(9):788-94. doi: 10.1007/s003920070183.

Abstract

Late postoperative arrhythmias are a common problem associated with significant morbidity following Fontan operations. We analyzed in our patients whether age at the time of a modified Fontan procedure (total cavopulmonary connection) has an influence on the frequency of late postoperative arrhythmias. We examined all 66 long-term surviving patients who underwent a total cavopulmonary connection (TCPC) in our center during a nine year period. At the time of TCPC, 31 children were younger (group I) and 35 children were older than 4 years (group II). The follow-up period was almost identical in both groups (group I: 4.29 years, group II: 4.52 years). We evaluated all ecgs performed at maximum intervals of 6 months and all Holter ecgs performed at intervals of 12 months. Atrial tachyarrhythmias (supraventricular tachycardias, atrial flutter) were registered in six patients (9%). All of these patients belonged to group II (17%). Ventricular arrhythmias (couplets, ventricular tachycardia) were found in 3% of the younger and 17% of the older patients. Abnormalities of sinus node function were registered in equal frequency in younger and older children (group I: 35%, group II: 31%), while pauses with a duration of > 2 s where present only in older children (group II: 14%). Pacemaker implantation or antiarrhythmic therapy became necessary in 10/66 patients (15%) affecting none of the children who underwent the TCPC < 4 years (group I) but 10/35 children (group II) who underwent the TCPC at an older age (29%). According to our findings in the medium-term follow-up after TCPC, atrial tachyarrhythmias and complex ventricular arrhythmias are registered less frequently in children who underwent the modified Fontan procedure at an age of less than 4 years. Although further studies will have to show whether these differences persist in the long-term follow-up, these findings represent an additional argument for the elective performance of modified Fontan operations at an age of less than 4 years.

摘要

术后晚期心律失常是与Fontan手术术后显著发病率相关的常见问题。我们分析了在我们的患者中,改良Fontan手术(全腔肺连接)时的年龄是否会对术后晚期心律失常的发生率产生影响。我们检查了在九年期间于我们中心接受全腔肺连接(TCPC)的所有66名长期存活患者。在进行TCPC时,31名儿童年龄较小(第一组),35名儿童年龄大于4岁(第二组)。两组的随访期几乎相同(第一组:4.29年,第二组:4.52年)。我们评估了每隔6个月进行的所有心电图以及每隔12个月进行的所有动态心电图。6名患者(9%)记录到房性快速心律失常(室上性心动过速、心房扑动)。所有这些患者均属于第二组(17%)。年龄较小的患者中有3%,年龄较大的患者中有17%发现室性心律失常(成对室性早搏、室性心动过速)。年龄较小和较大儿童中窦性节点功能异常的发生率相同(第一组:35%,第二组:31%),而持续时间>2秒的停搏仅出现在年龄较大的儿童中(第二组:14%)。10/66名患者(15%)需要植入起搏器或进行抗心律失常治疗,其中在4岁之前接受TCPC的儿童(第一组)均未出现这种情况,但在年龄较大时接受TCPC的10/35名儿童(第二组)出现了这种情况(29%)。根据我们在TCPC术后中期随访中的发现,在4岁以下接受改良Fontan手术的儿童中,房性快速心律失常和复杂性室性心律失常的发生率较低。尽管进一步的研究将不得不表明这些差异在长期随访中是否持续存在,但这些发现为在4岁以下选择性进行改良Fontan手术提供了额外的依据。

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