惊恐障碍的遗传学研究：综述
Genetic studies of panic disorder: a review.
作者信息
van den Heuvel O A, van de Wetering B J, Veltman D J, Pauls D L
机构信息
Department of Psychiatry and the Clinical PET Center, Academic Hospital Free University, Amsterdam, The Netherlands.
出版信息
J Clin Psychiatry. 2000 Oct;61(10):756-66. doi: 10.4088/jcp.v61n1008.
BACKGROUND
A review of the studies examining the genetic etiology of panic disorder shows the familial nature of the disorder and demonstrates that the etiology is greatly influenced by genetic factors. Strong evidence for vertical transmission in family studies led to molecular genetic studies, of which association designs appear promising, particularly when based on trait markers.
DATA SOURCES
The MEDLINE and PsycLIT databases were searched for all reports published between 1966 and 2000 containing the keywords panic, genetic, twin, adoption, linkage, association, and QTL.
CONCLUSION
We conclude that the multifactorial nature of panic disorder requires a multidisciplinary approach to gain insight into the determinants of the phenotype and the interaction of environmental and genetic factors.
背景
对研究惊恐障碍遗传病因的各项研究进行综述发现，该障碍具有家族性，且病因受遗传因素的影响很大。家族研究中垂直传递的有力证据促使了分子遗传学研究的开展，其中关联设计似乎很有前景，尤其是基于性状标记的关联设计。
数据来源
检索MEDLINE和PsycLIT数据库，查找1966年至2000年间发表的所有包含关键词“惊恐”“遗传”“双生子”“收养”“连锁”“关联”和“数量性状位点”的报告。
结论
我们得出结论，惊恐障碍的多因素性质需要采用多学科方法，以深入了解表型的决定因素以及环境和遗传因素的相互作用。
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