Battaglia M, Bertella S, Politi E, Bernardeschi L, Perna G, Gabriele A, Bellodi L
Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, University of Milan School of Medicine, Italy.
Am J Psychiatry. 1995 Sep;152(9):1362-4. doi: 10.1176/ajp.152.9.1362.
The authors investigated the relation of age at onset of panic disorder to liability to panic disorder and agoraphobia.
Two hundred thirty-one outpatients with panic disorder were compared with 131 surgical outpatients on demographic variables and familial risk of psychiatric disorders. The distribution of patients' ages at onset of panic disorder and several covariates were entered in a stepwise survival analysis.
The patients with panic disorder had a significantly higher rate of childhood separation anxiety disorder and higher familial risks of panic disorder/panic disorder with agoraphobia and alcoholism. A family history of panic disorder with agoraphobia and the presence of childhood separation anxiety disorder influenced age at onset of panic disorder.
Age at onset of panic disorder may reflect genetic penetrance, and separation anxiety disorder may be an individual predictor of earlier onset of panic disorder.
作者研究惊恐障碍起病年龄与惊恐障碍及广场恐惧症易感性之间的关系。
将231例惊恐障碍门诊患者与131例外科门诊患者在人口统计学变量和精神障碍家族风险方面进行比较。将惊恐障碍患者的起病年龄分布及几个协变量纳入逐步生存分析。
惊恐障碍患者童年分离焦虑障碍的发生率显著更高，惊恐障碍/伴广场恐惧症的惊恐障碍及酒精中毒的家族风险也更高。伴广场恐惧症的惊恐障碍家族史及童年分离焦虑障碍的存在影响惊恐障碍的起病年龄。
惊恐障碍的起病年龄可能反映基因外显率，分离焦虑障碍可能是惊恐障碍较早起病的个体预测因素。
