Patwari P, Weissman N J, Boppart S A, Jesser C, Stamper D, Fujimoto J G, Brezinski M E
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA.
Am J Cardiol. 2000 Mar 1;85(5):641-4. doi: 10.1016/s0002-9149(99)00825-5.
This study compares the ability of intravascular optical coherence tomography (OCT) and high-frequency intravascular ultrasound (IVUS) to image highly stenotic human coronary arteries in vitro. Current imaging modalities have insufficient resolution to perform risk stratification based on coronary plaque morphology. OCT is a new technology capable of imaging at a resolution of 5 to 20 microm, which has demonstrated the potential for coronary arterial imaging in prior experiments. Human postmortem coronary arteries with severely stenotic segments were imaged with catheter-based OCT and IVUS. The OCT system had an axial resolution of 20 microm and a transverse resolution of 30 microm. OCT was able to penetrate and image near-occlusive coronary plaques. Compared with IVUS, these OCT images demonstrated superior delineation of vessel layers and lack of ring-down artifact, leading to clearer visualization of the vessel plaque and intima. Histology confirmed the accuracy and high contrast of vessel layer boundaries seen on OCT images. Thus, catheter-based OCT systems are able to image near-occlusive coronary plaques with higher resolution than that of IVUS.
本研究比较了血管内光学相干断层扫描（OCT）和高频血管内超声（IVUS）在体外对高度狭窄的人体冠状动脉进行成像的能力。目前的成像方式分辨率不足，无法基于冠状动脉斑块形态进行风险分层。OCT是一项能够以5至20微米的分辨率进行成像的新技术，在先前的实验中已证明其在冠状动脉成像方面的潜力。使用基于导管的OCT和IVUS对具有严重狭窄节段的人体尸检冠状动脉进行成像。该OCT系统的轴向分辨率为20微米，横向分辨率为30微米。OCT能够穿透并对接近闭塞的冠状动脉斑块进行成像。与IVUS相比，这些OCT图像显示出血管层的描绘更清晰，且没有振铃伪像，从而使血管斑块和内膜的可视化更清晰。组织学证实了OCT图像上所见血管层边界的准确性和高对比度。因此，基于导管的OCT系统能够以比IVUS更高的分辨率对接近闭塞的冠状动脉斑块进行成像。
