Gurchot C
Oncology. 1975;31(5-6):310-33. doi: 10.1159/000225037.
Beard's theory can be restated in a modified form in modern terms in the following way. Cancer represents primarily trophoblastic tissue derived either from an aberrant germ cell or from a somatic cell whose normally repressed 'asexual generation' genes are abnormally reactivated ('derepressed'). The variety of tumors, other than teratomas, may be due to a parallel chance derepression of some genes of somatic ('sexual gneration') characters. This would be a defensive reaction against intramural parasitization by trophoblast and would result in the differentiation and hyperplasia of normally present more primative somatic cells.
比尔德的理论可以用现代术语以一种修改后的形式重新表述如下。癌症主要代表源自异常生殖细胞或体细胞的滋养层组织，其正常被抑制的“无性生殖”基因被异常重新激活（“去抑制”）。除畸胎瘤外的各种肿瘤，可能是由于体细胞（“有性生殖”）特征的某些基因平行偶然去抑制所致。这将是针对滋养层壁内寄生的一种防御反应，并会导致正常存在的更原始体细胞的分化和增生。
