胰腺腺癌患者血清中的β-人绒毛膜促性腺激素浓度
Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma.
作者信息
Syrigos K N, Fyssas I, Konstandoulakis M M, Harrington K J, Papadopoulos S, Milingos N, Peveretos P, Golematis B C
机构信息
1st Department of Propaedeutic Surgery, Athens Medical School, Hippokration Hospital, Greece.
出版信息
Gut. 1998 Jan;42(1):88-91. doi: 10.1136/gut.42.1.88.
BACKGROUND
Human chorionic gonadotropin (hCG) is normally produced and secreted by trophoblastic cells during pregnancy and from gestational trophoblastic neoplasms. It is also detected in ovarian, stomach, and colon adenocarcinomas, as well as in squamous cell carcinoma of the oesophagus. Recently, interest in its role in the pathogenesis of tumours has been enlivened after the presence of beta hCG in the cell membrane of several malignant cells was shown in vitro.
AIMS
To investigate the circulating concentrations of beta hCG in patients with exocrine pancreatic adenocarcinoma and to examine its potential prognostic value.
PATIENTS
Thirty six patients with exocrine pancreatic adenocarcinoma, 12 patients with chronic pancreatitis, and 21 healthy volunteers were studied.
METHODS
beta hCG serum concentrations were detected by the application of a radioimmunoassay technique.
RESULTS
Fifteen of 36 patients with pancreatic adenocarcinoma and only one patient with chronic pancreatitis had detectable plasma concentrations of beta hCG (p < 0.01). The patients with circulating serum titres of beta hCG had a worse outcome compared with the group of beta hCG negative patients: the difference was statistically significant (p = 0.01).
CONCLUSION
More than 40% of pancreatic exocrine tumours produce beta hCG and its production is correlated with an adverse effect on outcome.
背景
人绒毛膜促性腺激素（hCG）通常在妊娠期间由滋养层细胞产生和分泌，也可由妊娠滋养层肿瘤产生。在卵巢癌、胃癌和结肠癌以及食管鳞状细胞癌中也可检测到。最近，体外实验显示几种恶性细胞的细胞膜中存在β-hCG后，人们对其在肿瘤发病机制中的作用的兴趣被激发。
目的
研究外分泌型胰腺腺癌患者循环中β-hCG的浓度，并探讨其潜在的预后价值。
患者
研究了36例外分泌型胰腺腺癌患者、12例慢性胰腺炎患者和21名健康志愿者。
方法
应用放射免疫分析技术检测β-hCG血清浓度。
结果
36例胰腺腺癌患者中有15例以及仅1例慢性胰腺炎患者的血浆β-hCG浓度可检测到（p<0.01）。与β-hCG阴性患者组相比，循环血清β-hCG滴度阳性的患者预后较差：差异具有统计学意义（p = 0.01）。
结论
超过40%的胰腺外分泌肿瘤产生β-hCG，其产生与对预后的不良影响相关。
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