Denton M D, Davis S F, Baum M A, Melter M, Reinders M E, Exeni A, Samsonov D V, Fang J, Ganz P, Briscoe D M
Department of Medicine, Children's Hospital, Boston, MA, USA.
Pediatr Transplant. 2000 Nov;4(4):252-60. doi: 10.1034/j.1399-3046.2000.00031.x.
In this review, we discuss the role of the allograft endothelium in the recruitment and activation of leukocytes during acute and chronic rejection. We discuss associations among endothelial activation responses, the expression of adhesion molecules, chemokines and chemokine receptors, and rejection; and we propose that endothelial vascular cellular adhesion molecule-1 (VCAM-1) may be used as a surrogate marker of acute rejection and allograft vasculopathy. In addition, we describe potential mechanistic interpretations of persistent endothelial cell (EC) expression of major histocompatibility complex (MHC) class II molecules in allorecognition. The graft endothelium may provide an antigen-specific signal to transmigrating, previously activated, T cells and may induce B7 expression on locally transmigrating leukocytes to promote costimulation. Taken together, these functions of the EC provide it with a potent regulatory role in rejection and in the maintenance of T-cell activation via the direct and/or the indirect pathways of allorecognition.
在本综述中，我们讨论了同种异体移植物内皮在急性和慢性排斥反应期间白细胞募集和激活中的作用。我们讨论了内皮激活反应、黏附分子、趋化因子和趋化因子受体的表达与排斥反应之间的关联；并且我们提出内皮血管细胞黏附分子-1（VCAM-1）可用作急性排斥反应和移植物血管病变的替代标志物。此外，我们描述了在同种异体识别中主要组织相容性复合体（MHC）II类分子在内皮细胞（EC）持续表达的潜在机制解释。移植物内皮可能为迁移的、先前已激活的T细胞提供抗原特异性信号，并可能诱导局部迁移的白细胞上B7的表达以促进共刺激。综上所述，EC的这些功能使其在通过同种异体识别的直接和/或间接途径的排斥反应以及T细胞激活的维持中发挥强大的调节作用。
