Antiserotonin agents in the treatment of migraine.

The authors present the results of own investigations about the use of both pizotifen (SandomigranR) and cyproheptadine (PeritolR). 32 sufferers were treated with pizotifen and showed positive improvement in 68% of the cases. In this group no serious side effects were found. 20 patients before administration of the drug had placebo and this helped to establish the results statistically. 25 sufferers were treated with cyproheptadine and equally positive results in 64% of the cases. In this group were noted infrequent side effects. The results of the two tests were compared with the results of other tests done with other drug. From this it has been established that the antiserotonin drugs are the most effective at present in the treatment of migraine.