双盲临床研究：偏头痛患者每晚单剂量服用氟桂利嗪与苯噻啶的对比

[Double-blind clinical study: flunarizine versus pizotifen in a single nightly dose in hemicrania patients].

作者信息

Cerbo R, Casacchia M, Formisano R, Buzzi M G, Boni B, Feliciani M, Grillo G, Cusimano G, Agnoli A

出版信息

Riv Neurol. 1985 Mar-Apr;55(2):139-46.

Abstract

In this double-blind clinical trial we compared the prophylactic efficacy of the calcium-entry blocker flunarizine (15 mg nocte) with that of pizotifen (1,5 mg nocte). In 30 patients affected by classical and common migraine. During a two months treatment both drugs showed a good efficacy. Flunarizine tended to more markedly suppress severity of pain and duration of attacks than pizotifen. Daytime drowsiness and weight gain occurred with both drugs; the first side effect was more evident in the group treated with flunarizine, the second one in the group treated with pizotifen.

摘要

在这项双盲临床试验中，我们比较了钙通道阻滞剂氟桂利嗪（每晚15毫克）和苯噻啶（每晚1.5毫克）的预防效果。研究对象为30名患有典型常见偏头痛的患者。在为期两个月的治疗中，两种药物均显示出良好疗效。与苯噻啶相比，氟桂利嗪在更显著地抑制疼痛严重程度和发作持续时间方面更具优势。两种药物均出现了日间嗜睡和体重增加的情况；第一种副作用在氟桂利嗪治疗组中更为明显，第二种副作用在苯噻啶治疗组中更为明显。