Feany M B
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Neuropathol Exp Neurol. 2000 Oct;59(10):847-56. doi: 10.1093/jnen/59.10.847.
Invertebrate models of several human neurodegenerative diseases have recently been described. These models faithfully replicate key neuropathological features of the human disorders. Because the basic cell biology of the nervous system is very similar in vertebrates and invertebrates, the sophisticated and rapid genetic analysis feasible in Drosophila and C. elegans promises significant insight into human neurodegenerative syndromes. In addition, the short lifespan, small size, and ease of culturing make worms and flies ideal for drug testing.
最近已经描述了几种人类神经退行性疾病的无脊椎动物模型。这些模型忠实地复制了人类疾病的关键神经病理学特征。由于脊椎动物和无脊椎动物的神经系统基本细胞生物学非常相似，在果蝇和秀丽隐杆线虫中可行的复杂而快速的遗传分析有望为人类神经退行性综合征提供重要见解。此外，短寿命、小体型和易于培养使蠕虫和苍蝇成为药物测试的理想选择。
