Lepesant Jean-Antoine
Institut Jacques-Monod, CNRS UMR 7592, Université Paris-Diderot, 15, rue Hélène-Brion, 75205 Paris cedex 13, France.
C R Biol. 2015 Aug-Sep;338(8-9):584-92. doi: 10.1016/j.crvi.2015.06.018. Epub 2015 Jul 22.
The rise in the prevalence of neurodegenerative diseases parallels the rapid increase in human lifespan. Despite intensive research, the molecular and cellular mechanisms underlying the onset and progression of these devastating diseases with age are still poorly understood. Many aspects of these diseases have been modelled successfully in experimental animals such as the mouse, the zebrafish Brachydanio rero, the nematode worm Caenorhaditis elegans and the fruit fly Drosophila melanogaster. This review will focus on the advantages offered by the genetic tools available in Drosophila for combining powerful strategies in order to tackle the causative factors of these complex pathologies and help to elaborate efficient drugs to treat them.
神经退行性疾病患病率的上升与人类寿命的迅速增长同步。尽管进行了深入研究，但这些随年龄增长而出现的毁灭性疾病发病和进展的分子和细胞机制仍知之甚少。这些疾病的许多方面已在实验动物中成功建模，如小鼠、斑马鱼、线虫秀丽隐杆线虫和果蝇。本综述将重点关注果蝇中可用的遗传工具所提供的优势，这些工具可用于结合强大的策略，以应对这些复杂病症的致病因素，并有助于研发有效的治疗药物。
