Grossman K J, Stein D G
Department of Psychology, Emory University, 532 N. Kilgo Circle, Atlanta, GA 30322, USA.
Behav Brain Res. 2000 Dec 5;116(2):141-8. doi: 10.1016/s0166-4328(00)00275-8.
We studied sensorimotor recovery in male, normal-cycling and pseudopregnant female rats following unilateral FL-SMC contusions. Forelimb use (push off before a rear, support against the walls, and landing after a rear) and the foot fault test (foot misplacements during locomotion on an elevated grid) were analyzed from videotapes taken before surgery, and then again on post-surgical days 2 and 36. High endogenous progesterone levels in females at the time of injury did not affect recovery as there were no differences between males, pseudopregnant females and normal-cycling female rats on these behaviors. None of the brain-injured rats recovered symmetrical forelimb use between 2 and 36 days after injury (P>0.05) and they also showed foot misplacements (P>0.05) in the foot fault test. Male and female rats with contusions had fewer mean foot misplacements on day 36 than 2 days after injury (P<0.001), indicating that there was partial recovery on this task. These results were taken to show that there were no sex differences in motor deficits caused by unilateral FL-SMC injury. In addition, higher endogenous progesterone levels in females did not protect them from the chronic sensorimotor deficits caused by unilateral FL-SMC contusions.
我们研究了单侧FL-SMC挫伤后雄性、正常发情周期和假孕雌性大鼠的感觉运动恢复情况。从手术前拍摄的录像带中分析前肢使用情况（后肢蹬地前的推离、靠墙支撑以及后肢蹬地后的着地）和足部失误测试（在高架网格上行走时足部位置错误），然后在术后第2天和第36天再次进行分析。损伤时雌性大鼠体内高内源性孕酮水平并未影响恢复，因为在这些行为上雄性、假孕雌性和正常发情周期雌性大鼠之间没有差异。脑损伤大鼠在损伤后2至36天内均未恢复对称的前肢使用（P>0.05），并且在足部失误测试中也表现出足部位置错误（P>0.05）。有挫伤的雄性和雌性大鼠在第36天的平均足部位置错误比损伤后2天少（P<0.001），表明在此任务上有部分恢复。这些结果表明，单侧FL-SMC损伤引起的运动缺陷不存在性别差异。此外，雌性大鼠体内较高的内源性孕酮水平并不能保护它们免受单侧FL-SMC挫伤引起的慢性感觉运动缺陷的影响。
