Chrousos G P
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1583, USA.
J Allergy Clin Immunol. 2000 Nov;106(5 Suppl):S275-91. doi: 10.1067/mai.2000.110163.
The importance of T(H) cells (specifically T(H)2 cells) that produce IL-4, -5, -10, and -13 in the propagation of chronic allergic inflammation is well known. However, the role of the hypothalamic-pituitary-adrenal axis and the sympathetic system as immunomodulators of events leading to inflammation is less well established. Increases in stress levels are associated with elevations in circulating glucocorticoids and catecholamines, which may influence disease pathophysiologic factors and severity through changes in the number and activity of T(H)-cell populations and through other means. For instance, stress has been shown to shift the relative proportion and trafficking of T(H)1 and T(H)2 cells to a T(H)2 phenotype. In this article, the current understanding of interactions of the stress and immune systems and the physiologic and pathophysiologic implications of these interactions in human health and disease are reviewed.
产生白细胞介素-4、-5、-10和-13的辅助性T细胞（特别是Th2细胞）在慢性变应性炎症传播中的重要性已广为人知。然而，下丘脑-垂体-肾上腺轴和交感神经系统作为导致炎症事件的免疫调节因子的作用尚不十分明确。应激水平升高与循环糖皮质激素和儿茶酚胺升高有关，这可能通过Th细胞群体数量和活性的变化以及其他方式影响疾病的病理生理因素和严重程度。例如，应激已被证明可使Th1和Th2细胞的相对比例和迁移倾向转变为Th2表型。本文综述了目前对应激与免疫系统相互作用的认识，以及这些相互作用对人类健康和疾病的生理和病理生理影响。
