Holly S P, Larson M K, Parise L V
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Exp Cell Res. 2000 Nov 25;261(1):69-74. doi: 10.1006/excr.2000.5040.
Motility is essential for many important biological events, including embryonic development, inflammatory responses, wound healing, and tumor metastasis. During these events cells are in dynamic contact with the extracellular matrix through integrins. Integrins are the primary receptors for extracellular matrix proteins and consequently are required for cell motility. Cells have evolved multiple mechanisms to modulate integrin adhesive functions, which impact cell migration. In addition to providing a mechanism that allows cells to contact the extracellular matrix, integrins also promote intracellular signals that stimulate and regulate cell movement. Here we discuss the role of integrins during the multiple steps of cell migration.
细胞运动对于许多重要的生物学过程至关重要，包括胚胎发育、炎症反应、伤口愈合和肿瘤转移。在这些过程中，细胞通过整合素与细胞外基质进行动态接触。整合素是细胞外基质蛋白的主要受体，因此是细胞运动所必需的。细胞已经进化出多种机制来调节整合素的黏附功能，这会影响细胞迁移。除了提供一种使细胞能够接触细胞外基质的机制外，整合素还能促进刺激和调节细胞运动的细胞内信号。在这里，我们讨论整合素在细胞迁移多个步骤中的作用。
