Cox E A, Huttenlocher A
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana 61801, USA.
Microsc Res Tech. 1998 Dec 1;43(5):412-9. doi: 10.1002/(SICI)1097-0029(19981201)43:5<412::AID-JEMT7>3.0.CO;2-F.
Migrating cells form dynamic and highly regulated adhesive interactions with their environment. In particular, integrin-mediated adhesions to the extracellular matrix (ECM) play a central role in cell migration. This review focuses on recent advances in understanding the adhesive mechanisms that regulate cell detachment at the rear of migrating fibroblasts and neutrophils. The contribution of several key adhesive regulators is discussed, including myosin mediated cell contractility, tyrosine phosphorylation, rho, calcium fluxes, and calpain. A challenge for future investigation will be to determine how adhesive events are spatially and temporally coordinated to promote productive directional cell movements.
迁移细胞与周围环境形成动态且高度受调控的黏附相互作用。特别是，整合素介导的与细胞外基质（ECM）的黏附在细胞迁移中起核心作用。本综述聚焦于在理解调控迁移成纤维细胞和中性粒细胞后部细胞脱离的黏附机制方面的最新进展。讨论了几种关键黏附调节因子的作用，包括肌球蛋白介导的细胞收缩性、酪氨酸磷酸化、rho、钙通量和钙蛋白酶。未来研究面临的一个挑战将是确定黏附事件如何在空间和时间上协调，以促进有效的定向细胞运动。
