Glukhova M A, Thiery J P
Laboratoire de Physiopathologie du Developpement, CNRS (URA 1337) Paris, France.
Semin Cancer Biol. 1993 Aug;4(4):241-9.
Extracellular matrix glycoprotein fibronectin and integrins, transmembrane receptors for extracellular matrix proteins, have been implicated in morphogenesis, cytodifferentiation and organogenesis. During development, embryonic cells move on or through fibronectin-rich matrices, which support migration and contain the guidance cues that direct the cells along their migratory pathways. Integrins are involved in different aspects of the movement, including recognition of the pathway, transient attachment to the substrate and cytoskeleton rearrangement in the moving cells as well as organization of the matrix during migratory pathway formation. Differentiated tissues exhibit a characteristic and often rather limited set of integrins. On the contrary, during development, tissue repertoire of integrins changes, and integrins that are absent from the adult differentiated tissue may appear transiently and be expressed only during certain developmental stages. These periods of transient expression coincide with cell movement, differentiation and maturation of cells and can be correlated with changes of environment, i.e. neighboring cells, composition and structure of the extracellular matrix. In this article we discuss the recent data on the roles of fibronectin-integrin interactions in directed cell migration in embryos and on the distribution and possible functions of integrins in developing tissues.
细胞外基质糖蛋白纤连蛋白和整联蛋白（细胞外基质蛋白的跨膜受体）与形态发生、细胞分化和器官发生有关。在发育过程中，胚胎细胞在富含纤连蛋白的基质上移动或穿过该基质，这种基质支持细胞迁移，并包含引导细胞沿其迁移路径的导向线索。整联蛋白参与迁移的不同方面，包括对路径的识别、与底物的短暂附着以及移动细胞中的细胞骨架重排，以及迁移路径形成过程中基质的组织。分化组织表现出一组特征性且通常相当有限的整联蛋白。相反，在发育过程中，整联蛋白的组织组成会发生变化，成年分化组织中不存在的整联蛋白可能会短暂出现，并且仅在某些发育阶段表达。这些短暂表达期与细胞移动、细胞分化和成熟同时发生，并且可以与环境变化相关，即相邻细胞、细胞外基质的组成和结构。在本文中，我们讨论了关于纤连蛋白 - 整联蛋白相互作用在胚胎中定向细胞迁移中的作用以及整联蛋白在发育组织中的分布和可能功能的最新数据。
