老年抑郁症患者眶额皮质体积减小
Reduction of orbital frontal cortex volume in geriatric depression.
作者信息
Lai T, Payne M E, Byrum C E, Steffens D C, Krishnan K R
机构信息
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
出版信息
Biol Psychiatry. 2000 Nov 15;48(10):971-5. doi: 10.1016/s0006-3223(00)01042-8.
BACKGROUND
Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging.
METHODS
Twenty elderly patients meeting DSM-IV criteria for major depression and 20 matched control subjects were studied. The orbital frontal cortex was measured in both hemispheres using magnetic resonance imaging.
RESULTS
Depressive patients had reduced volume in the total orbital frontal cortex, right orbital frontal cortex, and left orbital frontal cortex.
CONCLUSIONS
Our finding of a reduction in orbital frontal cortex volume in both sides of the brain suggests that this region of the brain may have a critical role in the development of depression and raises questions about the etiology of the changes.
背景
尸检研究已证明抑郁症患者眶额内侧皮质存在异常。在本研究中，我们评估了能否使用磁共振成像在老年抑郁症患者中识别该区域的萎缩情况。
方法
对20名符合DSM-IV重度抑郁症标准的老年患者和20名匹配的对照受试者进行了研究。使用磁共振成像测量了双侧眶额皮质。
结果
抑郁症患者的总眶额皮质、右侧眶额皮质和左侧眶额皮质体积均减小。
结论
我们发现大脑两侧眶额皮质体积减小，这表明该脑区可能在抑郁症的发生中起关键作用，并引发了关于这些变化病因的疑问。
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