The Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA.
Psychiatry Res. 2011 Jul 30;193(1):1-6. doi: 10.1016/j.pscychresns.2011.01.003. Epub 2011 May 18.
Postmortem studies have documented abnormalities in the dorsolateral prefrontal cortex (dlPFC) in depressed subjects. In this study we used magnetic resonance imaging to test for dlPFC volume differences between older depressed and non-depressed individuals. Eighty-eight subjects meeting DSM IV criteria for major depressive disorder and thirty-five control subjects completed clinical evaluations and cranial 3T magnetic resonance imaging. After tissue types were identified using an automated segmentation process, the dlPFC was measured in both hemispheres using manual delineation based on anatomical landmarks. Depressed subjects had significantly lower gray matter in the left and right dorsolateral prefrontal cortex (standardized to cerebral parenchyma) after controlling for age and sex. Our study confirmed the reduction of dorsolateral prefrontal cortex in elderly depressed subjects, especially in the gray matter. These regional abnormalities may be associated with psychopathological changes in late-life depression.
尸检研究记录了抑郁患者背外侧前额皮质（dlPFC）的异常。在这项研究中，我们使用磁共振成像来测试老年抑郁和非抑郁个体之间的 dlPFC 体积差异。88 名符合 DSM-IV 重性抑郁障碍标准的患者和 35 名对照者完成了临床评估和颅 3T 磁共振成像。在使用自动分割过程识别组织类型后，使用基于解剖学标志的手动描绘法在两个半球测量 dlPFC。在控制年龄和性别后，抑郁患者的左侧和右侧背外侧前额皮质（标准化为脑实质）中的灰质明显减少。我们的研究证实了老年抑郁患者 dlPFC 的减少，尤其是灰质的减少。这些区域性异常可能与晚年抑郁症的精神病理学变化有关。
