Magnati G, Dei Cas A
Department of Internal Medicine and Biomedical Science, School of Medicine, University of Parma, Italy.
Eat Weight Disord. 2000 Sep;5(3):124-31. doi: 10.1007/BF03354442.
This paper reviews recent developments and findings regarding the role of the hypothalamus as the main site in the central nervous system (CNS) for regulating appetite. It contains a specific neural network consisting of the main central monoaminergic neurotransmitters (adrenaline, noradrenaline, dopamine, serotonin) and many neuropeptides with orexigenic and anorexigenic functions. The crucial relationship between CNS and obesity and the complex interconnections of CNS and peripheral peptides are becoming clearer. The mechanisms by which these hormones affect energy homeostasis through long and short-term anabolic and catabolic pathways are described. New anti-obesity therapeutic strategies based on drugs or molecules with new mechanisms of action, some not yet available in Italy but will soon be on the market, are considered.
本文综述了关于下丘脑作为中枢神经系统（CNS）中调节食欲主要部位的最新进展和研究结果。它包含一个特定的神经网络，由主要的中枢单胺能神经递质（肾上腺素、去甲肾上腺素、多巴胺、血清素）和许多具有促食欲和抑食欲功能的神经肽组成。中枢神经系统与肥胖之间的关键关系以及中枢神经系统与外周肽的复杂相互联系正变得越来越清晰。文中描述了这些激素通过长期和短期合成代谢及分解代谢途径影响能量稳态的机制。还考虑了基于具有新作用机制的药物或分子的新型抗肥胖治疗策略，其中一些在意大利尚未上市，但很快将投放市场。
