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[在埃尔巴格雷(哥伦比亚安蒂奥基亚省)职业性接触汞蒸气后出现的神经心理障碍]

[Pneuropsychological disorders after occupational exposure to mercury vapors in El Bagre (Antioquia, Colombia)].

作者信息

Tirado V, García M A, Moreno J, Galeano L M, Lopera F, Franco A

机构信息

Universidad de Antioquia, Medellin, Colombia.

出版信息

Rev Neurol. 2000;31(8):712-6.

PMID:11082875
Abstract

INTRODUCTION

The department of Antioquia in Columbia is the main producer of gold in Columbia. In the gold-producing regions the population is exposed to high levels of mercury used in the processes of extraction and purification. Studies done in Columbia on neurotoxicity underline the hazards of mercury from the environmental and occupational-health point of view, but the effect of long-term exposure on cognitive function has not been studied.

OBJECTIVE

To determine whether the miners of El Bagre (Antioquia, Columbia) have neuropsychological and/or behavior disorders as a result of occupational exposure to toxic mercury vapor.

PATIENTS AND METHODS

The sample was made up of 22 right-handed men, residents of El Bagre, aged between 20 and 45 years old who had been exposed to mercury vapor for at least three years. The control group consisted of 22 men who lived in the non-mining regions of the department and had not been exposed to mercury, paired with the cases considered for age and educational status. Neuropsychological assessment, a medical examination and behavioral performance tests were applied to all the men (in both groups).

RESULTS

In the study group alterations were seen and classified as: intellectual damage (mainly alteration of executive function and constructional praxis); emotional changes (symptoms of depression and anxiety) and neurological changes (amnesia, insomnia and tremor of the tongue). No changes were found in the control group.

CONCLUSION

Exposure to mercury causes specific neuropsychological and behavior disorders in the absence of clinically detectable physical or physiological damage.

摘要

引言

哥伦比亚的安蒂奥基亚省是该国主要的黄金产地。在黄金生产地区,当地居民在黄金开采和提纯过程中接触到高浓度的汞。哥伦比亚开展的有关神经毒性的研究从环境和职业健康角度强调了汞的危害,但长期接触汞对认知功能的影响尚未得到研究。

目的

确定埃尔巴格雷(哥伦比亚安蒂奥基亚省)的矿工是否因职业接触有毒汞蒸气而患有神经心理和/或行为障碍。

患者与方法

样本由22名右利手男性组成,他们均为埃尔巴格雷的居民,年龄在20至45岁之间,且接触汞蒸气至少三年。对照组由22名男性组成,他们生活在该省的非采矿区,未接触过汞,在年龄和教育程度上与病例组相匹配。对所有男性(两组)均进行了神经心理学评估、医学检查和行为表现测试。

结果

研究组出现了一些改变,并被分类为:智力损伤(主要是执行功能和结构运用能力的改变);情绪变化(抑郁和焦虑症状)以及神经学改变(失忆、失眠和舌震颤)。对照组未发现任何变化。

结论

在没有临床可检测到的身体或生理损伤的情况下,接触汞会导致特定的神经心理和行为障碍。

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Rev Neurol. 2000;31(8):712-6.
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