Schoner W
Institut für Biochemie und Endokrinologie, Justus-Liebig-Universität Giessen.
Exp Clin Endocrinol Diabetes. 2000;108(7):449-54. doi: 10.1055/s-2000-8140.
Ouabain has been isolated and identified as a constituent of human blood, bovine adrenal glands and hypothalamus. This water soluble inhibitor of the sodium pump (Na+/K+-ATPase) circulates in elevated concentrations in blood plasma of 50% of Caucasians with elevated blood pressure. It is released from adrenal cortical cells in tissue culture by angiotensin II. A ouabain antagonist, PST2238, lowers blood pressure in hypertensive rats. Hence, ouabain is most probably a new steroid hormone formed in adrenal glands and hypothalamus. Consistent therewith is the demonstration of a specific binding globulin for cardiac glycosides in blood plasma.
哇巴因已被分离出来，并被鉴定为人血、牛肾上腺和下丘脑的一种成分。这种钠泵（Na+/K+-ATP酶）的水溶性抑制剂在50%血压升高的高加索人的血浆中以较高浓度循环。它在组织培养中由血管紧张素II从肾上腺皮质细胞中释放出来。一种哇巴因拮抗剂PST2238可降低高血压大鼠的血压。因此，哇巴因很可能是一种在肾上腺和下丘脑中形成的新的类固醇激素。与此相一致的是，血浆中存在一种针对强心苷的特异性结合球蛋白。
