Kardos T B, Heslop B F
Transplantation. 1975 Nov;20(5):381-4. doi: 10.1097/00007890-197511000-00004.
Orthotopic and heterotopic tooth allografts stimulated the production of alloantibodies in rats incompatible at the major histocompatibility locus. The immunogenicity of whole tooth grafts was slightly diminished but not eliminated by sealing the pulp cavity prior to grafting. Suspensions of dentine in saline elicited alloantibody formation on i.p. injection into allogeneic hosts. Orthotopic tooth allografts, but not heterotopic grafts, were as effective as skin allografts at stimulating second set rejection of challenging skin grafts. Orthotopic tooth allografts were indistinguishable from syngeneic grafts on histological examination over the period 1-6 weeks after grafting. The occurrence of alloantibody formation after tooth grafting was capricious, and this, combined with the histological difficulty of distinguishing syngeneic from allogeneic grafts, and also the differing capacity of orthotopic and heterotopic tooth allografts to provoke accelerated skin grafts rejection, probably accounts for some of the differences of opinion expressed previously on the immunogenicity of grafted teeth.
在主要组织相容性位点不相容的大鼠中，原位和异位牙同种异体移植刺激了同种抗体的产生。在移植前封闭牙髓腔，全牙移植物的免疫原性略有降低但并未消除。牙本质生理盐水悬液经腹腔注射到同种异体宿主中可引发同种抗体形成。原位牙同种异体移植，而非异位移植，在刺激挑战性皮肤移植物的二次排斥反应方面与皮肤同种异体移植效果相同。在移植后1 - 6周的组织学检查中，原位牙同种异体移植与同基因移植物没有区别。牙移植后同种抗体形成的情况变幻莫测，再加上在组织学上区分同基因移植物和同种异体移植物存在困难，以及原位和异位牙同种异体移植引发加速皮肤移植物排斥反应的能力不同，这可能解释了之前关于移植牙免疫原性的一些不同观点。
