艾滋病病毒/艾滋病患者中冷漠、抑郁与认知障碍之间的关系。
Relationships among apathy, depression, and cognitive impairment in HIV/AIDS.
作者信息
Rabkin J G, Ferrando S J, van Gorp W, Rieppi R, McElhiney M, Sewell M
机构信息
Department of Psychiatry, Weill Medical College of Cornell University, New York, New York, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2000 Fall;12(4):451-7. doi: 10.1176/jnp.12.4.451.
This study was designed to determine whether apathy is associated with neurocognitive symptoms and/or depressive symptoms in HIV/AIDS and also whether apathy is associated with patient expectancies about antiretroviral medication adherence. Seventy-five HIV+ homosexual men and 58 HIV+ women were assessed for depressive disorders and symptoms. Neuropsychological tests measured attention, concentration, learning, memory, executive function, and psychomotor speed. Other measures included Marin's Apathy Evaluation Scale, the Adherence Determinants Questionnaire, CD4 cell count, and HIV RNA viral load. Apathy was consistently related to depression and unrelated to neuropsychological impairment. Patient expectancies regarding medication adherence were unrelated to apathy when the analysis was controlled for depressive symptoms.
本研究旨在确定冷漠是否与艾滋病毒/艾滋病患者的神经认知症状和/或抑郁症状相关，以及冷漠是否与患者对抗逆转录病毒药物依从性的预期相关。对75名艾滋病毒呈阳性的同性恋男性和58名艾滋病毒呈阳性的女性进行了抑郁障碍和症状评估。神经心理学测试测量注意力、专注力、学习、记忆、执行功能和精神运动速度。其他测量指标包括马林冷漠评估量表、依从性决定因素问卷、CD4细胞计数和艾滋病毒RNA病毒载量。冷漠与抑郁始终相关，与神经心理损伤无关。在对抑郁症状进行分析控制后，患者对药物依从性的预期与冷漠无关。
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