白细胞介素12作为WI-1黏附素免疫的佐剂，可增强迟发型超敏反应，改变免疫球蛋白G抗体的亚类分布，并增强对皮炎芽生菌感染的保护性免疫。
Interleukin 12 as an adjuvant to WI-1 adhesin immunization augments delayed-type hypersensitivity, shifts the subclass distribution of immunoglobulin G antibodies, and enhances protective immunity to Blastomyces dermatitidis infection.
作者信息
Wüthrich M, Finkel-Jiminez B E, Klein B S
机构信息
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA.
出版信息
Infect Immun. 2000 Dec;68(12):7172-4. doi: 10.1128/IAI.68.12.7172-7174.2000.
Abstract
Cell-mediated immunity is pivotal in host resistance to Blastomyces dermatitidis infection. Immunization of mice with the WI-1 adhesin enhances resistance against experimental pulmonary infection but elicits features of a mixed T-helper-cell immune response. Immune mice acquire delayed-type hypersensitivity (DTH) but also high titers of WI-1-specific immunoglobulin G1 (IgG1) and IgG2b, a result indicative of T-helper-2 cellular immunity. We report that interleukin-12, used as an adjuvant for WI-1 immunization, augments DTH, shifts the balance of the T-helper phenotype toward Th1, and enhances resistance to B. dermatitidis infection.
摘要
细胞介导的免疫在宿主抵抗皮炎芽生菌感染中起关键作用。用WI-1黏附素免疫小鼠可增强对实验性肺部感染的抵抗力，但会引发混合性辅助性T细胞免疫反应的特征。免疫小鼠获得了迟发型超敏反应（DTH），同时还产生了高滴度的WI-1特异性免疫球蛋白G1（IgG1）和IgG2b，这一结果表明存在辅助性T细胞2型细胞免疫。我们报告称，白细胞介素-12作为WI-1免疫的佐剂，可增强DTH，使辅助性T细胞表型的平衡向Th1偏移，并增强对皮炎芽生菌感染的抵抗力。
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