Cozad G C, Chang C T
Infect Immun. 1980 May;28(2):398-403. doi: 10.1128/iai.28.2.398-403.1980.
Delayed hypersensitivity can be induced in C57BL/6J mice by two subcutaneous injections of Merthiolate-killed Blastomyces dermatitidis yeast cells in Freund incomplete adjuvant. Development of delayed hypersensitivity peaked at the day 18 post-primary antigen-emulsion injection, as determined by footpad sensitivity tests. Mice rendered hypersensitive to B. dermatitidis were protected from the lethal effect of a blastomyces infection. The protection effects were shown both in mortality tests and in data from organ cultures as expressed by indices of resistance. Data from this study show that there is a close parallel relationship between host resistance and the prevailing level of delayed hypersensitivity.
通过在弗氏不完全佐剂中皮下注射两次硫柳汞灭活的皮炎芽生菌酵母细胞，可在C57BL/6J小鼠中诱导迟发型超敏反应。通过足垫敏感性试验确定，迟发型超敏反应在初次抗原乳剂注射后第18天达到峰值。对皮炎芽生菌产生超敏反应的小鼠可免受芽生菌感染的致死效应。在死亡率试验和器官培养数据中均显示出保护作用，以抗性指数表示。本研究数据表明，宿主抗性与迟发型超敏反应的流行水平之间存在密切的平行关系。
