迟发型超敏反应在小鼠芽生菌病中的作用。
Role of delayed hypersensitivity in blastomycosis of mice.
作者信息
Spencer H D, Cozad G C
出版信息
Infect Immun. 1973 Mar;7(3):329-34. doi: 10.1128/iai.7.3.329-334.1973.
Abstract
C57BL/6J mice rendered hypersensitive to Blastomyces dermatitidis were protected from the lethal effects of a blastomyces infection. This protection was observed following a lethal intraperitoneal challenge with viable cells 15 days after subcutaneous inoculation with 3.9 x 10(4) viable cells. Delayed hypersensitivity was induced in C57 mice by two injections of Merthiolate-killed cells in adjuvant or by a single injection of viable cells. Development of hypersensitivity was determined at appropriate intervals by footpad injection with killed yeast cells.
摘要
对皮炎芽生菌致敏的C57BL/6J小鼠可免受芽生菌感染的致死效应。在用3.9×10⁴个活细胞皮下接种15天后，经腹腔注射活细胞进行致死性攻击后观察到了这种保护作用。通过在佐剂中两次注射硫柳汞灭活的细胞或单次注射活细胞，在C57小鼠中诱导迟发型超敏反应。在适当的间隔时间，通过足垫注射灭活酵母细胞来确定超敏反应的发展情况。
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