Alvarez-Coca González J, Cebrero García M, Vecilla Rivelles M C, Alonso Cristobo M, Torrijos Roman C
Servicio de Pediatría, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
An Esp Pediatr. 2000 Oct;53(4):366-8.
Up to 40% of ceftriaxone is excreted unchanged into the bile and, due to its high calcium-binding affinity, it may form a salt that can provoke biliary lithiasis. Echography revealed that biliary lithiasis was present in 12-45% of patients treated with ceftriaxone as early as the second day of treatment. Lithiasis is usually asymptomatic and disappears in less than 2 months. Symptomatic cases and patients requiring cholecystectomy have been described in the literature. We present four children, evaluated in 1999, who presented asymptomatic cholelithiasis between the second and fourth day of ceftriaxone treatment. Biliary lithiasis was found after 2-4 days of treatment, with resolution of the lithiasis between 1-4 months after the end of therapy.
高达40%的头孢曲松以原形经胆汁排泄，由于其对钙的高结合亲和力，它可能形成一种可引发胆石症的盐。超声检查显示，早在治疗第二天，接受头孢曲松治疗的患者中12% - 45%存在胆石症。结石通常无症状，且在不到2个月内消失。文献中已描述了有症状的病例以及需要进行胆囊切除术的患者。我们报告了1999年评估的4名儿童，他们在头孢曲松治疗的第二天至第四天出现无症状胆结石。治疗2 - 4天后发现胆石症，治疗结束后1 - 4个月结石消退。
