链状泛素。

Ubiquitin in chains.

作者信息

Pickart C M

机构信息

Dept of Biochemistry and Molecular Biology, School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

出版信息

Trends Biochem Sci. 2000 Nov;25(11):544-8. doi: 10.1016/s0968-0004(00)01681-9.

DOI:10.1016/s0968-0004(00)01681-9

PMID:11084366

Abstract

The ubiquitin-proteasome system fulfills an essential function in eukaryotes by controlling the levels of crucial intracellular regulatory proteins. In this system, a specific type of polyubiquitin chain acts as the proximal signal for targeting substrates to 26S proteasomes for degradation. Recent results have revealed important determinants of polyubiquitin-chain recognition by proteasomes, helping to explain the biological rationale behind this novel signaling mechanism.

摘要

泛素-蛋白酶体系统通过控制关键细胞内调节蛋白的水平，在真核生物中发挥着至关重要的作用。在这个系统中，一种特定类型的多聚泛素链作为将底物靶向26S蛋白酶体进行降解的近端信号。最近的研究结果揭示了蛋白酶体识别多聚泛素链的重要决定因素，有助于解释这种新型信号机制背后的生物学原理。