Paek B W, Farmer D L, Wilkinson C C, Albanese C T, Peacock W, Harrison M R, Jennings R W
Division of Pediatric Surgery, Department of Surgery, and The Fetal Treatment Center, University of California at San Francisco, 94143-0570, USA.
Am J Obstet Gynecol. 2000 Nov;183(5):1119-23. doi: 10.1067/mob.2000.108867.
The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model.
A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation.
In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal.
Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.
我们研究的目的是确定脊髓脊膜膨出的产前修复是否能预防或逆转绵羊模型中的后脑疝形成。
在胎羊身上手术制造脊髓脊膜膨出。一组在子宫内后期进行修复；其他组未修复就分娩。分娩后，评估羔羊是否存在后脑疝。
在所有未进行脊髓脊膜膨出修复的羔羊中，均出现严重的后脑疝，而所有接受胎儿期修复的羔羊大脑均正常。
在胎羊模型中，脊髓脊膜膨出的产前修复可预防或逆转后脑疝的发展。
