后脑疝出在手术制造的脊髓脊膜膨出中出现，但在胎羊修复后不存在。
Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs.
作者信息
Paek B W, Farmer D L, Wilkinson C C, Albanese C T, Peacock W, Harrison M R, Jennings R W
机构信息
Division of Pediatric Surgery, Department of Surgery, and The Fetal Treatment Center, University of California at San Francisco, 94143-0570, USA.
出版信息
Am J Obstet Gynecol. 2000 Nov;183(5):1119-23. doi: 10.1067/mob.2000.108867.
OBJECTIVE
The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model.
STUDY DESIGN
A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation.
RESULTS
In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal.
CONCLUSION
Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.
目的
我们研究的目的是确定脊髓脊膜膨出的产前修复是否能预防或逆转绵羊模型中的后脑疝形成。
研究设计
在胎羊身上手术制造脊髓脊膜膨出。一组在子宫内后期进行修复；其他组未修复就分娩。分娩后，评估羔羊是否存在后脑疝。
结果
在所有未进行脊髓脊膜膨出修复的羔羊中，均出现严重的后脑疝，而所有接受胎儿期修复的羔羊大脑均正常。
结论
在胎羊模型中，脊髓脊膜膨出的产前修复可预防或逆转后脑疝的发展。
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