Anderson G, Harman B C, Hare K J, Jenkinson E J
Department of Anatomy, MRC Centre for Immune Regulation Medical School, University of Birmingham, UK.
Semin Immunol. 2000 Oct;12(5):457-64. doi: 10.1006/smim.2000.0260.
T cell development in the thymus occurs through a series of events beginning with thymic colonization by migrant precursors and ending with the emigration of functionally competent CD4+ and CD8+ T cells to the periphery. It is well accepted that signals through the pre-T cell receptor (pre-TCR) and alpha-beta TCR (alphabetaTCR) complex play pivotal roles in the maturation of CD4-8- and CD4+8+ thymocytes, respectively. It is clear that stromal cells constituting the thymic microenvironment provide non-TCR-mediated interactions which are essential for several developmental events. Examples of such will be discussed here in relation to early and late events in T cell development.
胸腺中的T细胞发育通过一系列事件发生，始于迁移前体细胞对胸腺的定植，终于功能成熟的CD4+和CD8+ T细胞向外周血的迁移。人们普遍认为，通过前T细胞受体（pre-TCR）和α-β TCR（αβTCR）复合体传递的信号分别在CD4-8-和CD4+8+胸腺细胞的成熟过程中起关键作用。显然，构成胸腺微环境的基质细胞提供非TCR介导的相互作用，这对几个发育事件至关重要。本文将结合T细胞发育的早期和晚期事件讨论此类例子。
