Laky Karen, Fleischacker Christine, Fowlkes B J
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0420, USA.
Immunol Rev. 2006 Feb;209:274-83. doi: 10.1111/j.0105-2896.2006.00358.x.
The generation of CD4 and CD8 alphabeta T-cell lineages from CD4+ CD8+ double-positive (DP) thymocyte precursors is a complex process initiated by engagement of major histocompatibility complex (MHC) by T-cell receptor (TCR) and coreceptor. Quantitative differences in TCR signaling induced by this interaction impose an instructional bias on CD4/CD8 lineage commitment that must be reinforced by MHC recognition and TCR signaling over subsequent selection steps in order for the thymocyte to progress and mature in the adopted lineage. Our studies show that the transmembrane receptor Notch plays a role in this process by modifying TCR signal transduction in DP thymocytes. In this review, we consider the functional relationship of TCR and Notch signaling pathways in the selection and specification of CD4 and CD8 T-cell lineages.
从CD4⁺CD8⁺双阳性（DP）胸腺细胞前体生成CD4和CD8αβ T细胞谱系是一个复杂的过程，该过程由T细胞受体（TCR）和共受体与主要组织相容性复合体（MHC）的结合所启动。这种相互作用诱导的TCR信号传导的定量差异对CD4/CD8谱系定向施加了一种指导性偏差，在随后的选择步骤中，必须通过MHC识别和TCR信号传导来加强这种偏差，以便胸腺细胞在所采用的谱系中进展和成熟。我们的研究表明，跨膜受体Notch通过修饰DP胸腺细胞中的TCR信号转导在这一过程中发挥作用。在这篇综述中，我们考虑了TCR和Notch信号通路在CD4和CD8 T细胞谱系选择和定向中的功能关系。
