尼日利亚西南部一个农村社区儿童中的无症状疟疾与肠道蠕虫合并感染

Asymptomatic malaria and intestinal helminth co-infection among children in a rural community in Southwest Nigeria.

作者信息

Dada-Adegbola Hannah O, Oluwatoba Olufunke A, Falade Catherine O

机构信息

Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Department of Pharmacology & Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

出版信息

Malariaworld J. 2013 Dec 12;4:18. doi: 10.5281/zenodo.10928310. eCollection 2013.

DOI:10.5281/zenodo.10928310

PMID:38828121

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11138751/

Abstract

BACKGROUND

Malaria is prevalent in sub-Saharan Africa, where other concomitant parasitic infections, including intestinal helminths, are common. However, little is known about how concurrent infections affect the expression or pathogenesis of each other. This study aimed to document the prevalence rates of malaria and intestinal helminths individually and as co-infection among asymptomatic children in a rural community in southwest Nigeria.

MATERIALS AND METHODS

Apparently healthy children aged 1-17 years, who were enrolled into a larger study that evaluated the efficacy and safety of two anti-helminthic drugs, were evaluated for intestinal helminths by stool examination using the saline wet mount and Kato-Katz methods. Capillary blood from finger prick samples was used for haematocrit determination and malaria screening by microscopy. Data analysis was conducted using SPSS and significance levels were set at p < 0.05.

RESULTS

Eighty-nine of 178 (50%) enrolees were male. One hundred and fifteen of the 178 (64.6%) children had at least one intestinal helminthic infection while 69 (60%) thereof harboured multiple helminthic infections. Malaria parasites were encountered in 35/178 (19.7%) of the enrolees. Parasite density was ≤500/μl in 51.4% (18/35), 501-1,000/μl in 9 (25.7%) and 1,000-4,720/μl in 8 (22.9%) of the children. Malaria-helminth co-infection was detected in 24/115 (20.9%) of the children. The prevalence [60/115 (52.2%) versus 8/63 (12.7%) p<0.0001] and severity of anaemia were significantly higher among children with worms compared to those without worms. For mild anaemia this was 53/115 (46.8%; with worms) versus 7/63 (11.1%; no worms p<0.0001); for moderate anaemia 2/115 (1.74%; with worms) versus 1/63 (1.59%; without worms; p<0.271).

CONCLUSION

Malaria and helminths co-infection is common among apparently asymptomatic children in the rural community studied. Co-infections increase the problems associated with anaemia and aggravate the burden of disease in Nigerian children.

摘要

背景

疟疾在撒哈拉以南非洲地区流行，在该地区，包括肠道蠕虫在内的其他伴随寄生虫感染也很常见。然而，对于同时感染如何相互影响彼此的表达或发病机制，人们知之甚少。本研究旨在记录尼日利亚西南部一个农村社区无症状儿童中疟疾和肠道蠕虫各自以及合并感染的患病率。

材料与方法

年龄在1至17岁、表面健康且参与一项评估两种抗蠕虫药物疗效和安全性的更大规模研究的儿童，采用生理盐水湿涂片法和加藤厚涂片法通过粪便检查评估肠道蠕虫感染情况。用手指针刺取的毛细血管血用于测定血细胞比容和通过显微镜进行疟疾筛查。使用SPSS进行数据分析，显著性水平设定为p < 0.05。

结果

178名受试者中有89名（50%）为男性。178名儿童中有115名（64.6%）至少感染一种肠道蠕虫，其中69名（60%）感染多种蠕虫。178名受试者中有35名（19.7%）检测到疟原虫。51.4%（18/35）的儿童寄生虫密度≤500/μl，9名（25.7%）儿童的寄生虫密度为501 - 1000/μl，8名（22.9%）儿童的寄生虫密度为1000 - 4720/μl。在115名感染蠕虫的儿童中有24名（20.9%）检测到疟疾 - 蠕虫合并感染。与未感染蠕虫的儿童相比，感染蠕虫的儿童贫血患病率[60/115（52.2%）对8/63（12.7%），p<0.0001]和严重程度显著更高。对于轻度贫血，感染蠕虫的儿童为53/115（46.8%），未感染蠕虫的儿童为7/63（11.1%），p<0.0001；对于中度贫血，感染蠕虫的儿童为2/115（1.74%），未感染蠕虫的儿童为1/63（1.59%），p<0.271。