Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system.

作者信息

Kalf G F

机构信息

Department of Biochemistry and Molecular Pharmacology, Kimmel Cancer Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

出版信息

J Toxicol Environ Health A. 2000 Nov;61(5-6):399-411. doi: 10.1080/00984100050166424.

DOI:10.1080/00984100050166424

PMID:11086946

Abstract

摘要

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Utility of a mouse model for studying the effects of benzene on the myeloid lineage: effects of hydroquinone on a model myeloid system.

J Toxicol Environ Health A. 2000 Nov;61(5-6):399-411. doi: 10.1080/00984100050166424.

Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone.苯和对苯二酚在小鼠模型中诱导粒细胞分化

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Induction of granulocytic differentiation in myeloblasts by hydroquinone, a metabolite of benzene, involves the leukotriene D4 receptor.苯的代谢产物对苯二酚诱导成髓细胞向粒细胞分化涉及白三烯D4受体。

Recept Signal Transduct. 1996;6(1):1-12.

Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony-stimulating factor.苯及其代谢产物对苯二酚通过与粒细胞集落刺激因子激活的细胞信号通路相互作用，诱导成髓细胞向粒细胞分化。

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Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1.Nup98-HoxA9使髓系祖细胞永生化，增强Hoxa9、Hoxa7和Meis1的表达，并以类似于Hoxa9和Meis1逆转录病毒共表达所诱导的方式改变细胞因子特异性反应。

Oncogene. 2002 Jun 20;21(27):4247-56. doi: 10.1038/sj.onc.1205516.

Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression.促红细胞生成素通过异位促红细胞生成素受体表达介导定向髓系细胞的终末粒细胞分化。

Eur J Haematol. 2001 Aug;67(2):77-87.

Hematopoietic growth factors and glucocorticoids synergize to mimic the effects of IL-1 on granulocyte differentiation and IL-1 receptor induction on bone marrow cells in vivo.造血生长因子和糖皮质激素协同作用，在体内模拟白细胞介素-1对粒细胞分化及骨髓细胞白细胞介素-1受体诱导的作用。

Exp Hematol. 1993 Feb;21(2):303-10.

Hydroquinone inhibits bone marrow pre-B cell maturation in vitro.对苯二酚在体外抑制骨髓前B细胞成熟。

Mol Pharmacol. 1987 Dec;32(6):807-12.

ERK expands its empire.细胞外信号调节激酶扩展其“版图”。

Leuk Res. 2005 Nov;29(11):1235-6. doi: 10.1016/j.leukres.2005.05.021.

Hydroquinone, a bioreactive metabolite of benzene, inhibits apoptosis in myeloblasts.对苯二酚是苯的一种生物活性代谢产物，可抑制成髓细胞的凋亡。

Stem Cells. 1996 Nov;14(6):730-42. doi: 10.1002/stem.140730.

引用本文的文献

Cytokine network involvement in subjects exposed to benzene.细胞因子网络参与苯暴露人群。

J Immunol Res. 2014;2014:937987. doi: 10.1155/2014/937987. Epub 2014 Aug 18.

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