Lu M, Kruppenbacher J, Roggendorf M
Institut für Virologie, Universitätsklinikum Essen, Germany.
Arch Virol. 2000;145(10):2201-10. doi: 10.1007/s007050070050.
The quasispecies populations of hepatitis C virus (HCV) in the infectious source (IS) and in patients of a single source outbreak were characterized. A predominant variant AD78-1 and some minor variants of HCV 5' NCR were identified in IS. Different complex HCV populations emerged rapidly in patients though HCV populations in chronic infection were rather simple and stable. AD78-1 remained predominant in 17/24 chronically infected patients while new predominant variants with distinct nucleotide substitutions persisted in 7 other patients. Thus, only distinct variants are involved in viral persistence and the genetic heterogeneity of HCV does not successively increase with time.
对传染源（IS）以及单一传染源暴发中的患者体内丙型肝炎病毒（HCV）的准种群体进行了特征分析。在传染源中鉴定出一种主要变体AD78-1以及HCV 5' NCR的一些次要变体。尽管慢性感染中的HCV群体相当简单且稳定，但患者体内迅速出现了不同的复杂HCV群体。AD78-1在17/24例慢性感染患者中仍占主导地位，而另外7例患者中持续存在具有不同核苷酸替换的新的主要变体。因此，只有不同的变体参与病毒持续存在，并且HCV的遗传异质性不会随时间连续增加。
