White W B
Section of Hypertension and Clinical Pharmacology, University of Connecticut School of Medicine, Farmington, Connecticut 06030-3940, USA.
Blood Press Monit. 2000;5 Suppl 2:S13-7. doi: 10.1097/00126097-200010002-00004.
Several specific features of ambulatory monitoring of the blood pressure have made it important in clinical trials that assess antihypertensive drug therapy. These include the removal of observer bias, improved short-term and long-term blood pressure reproducibility compared with clinic readings, elimination of the 'white-coat' effect during patient selection and the ability to assess the effects of long-acting once daily therapies on diurnal and nocturnal blood pressure. In this article, an overview of the utility of ambulatory blood pressure monitoring in clinical trials is provided, with specific examples that use data from recent studies of the newer compounds that block the renin-angiotensin system.
动态血压监测的几个特定特征使其在评估抗高血压药物治疗的临床试验中具有重要意义。这些特征包括消除观察者偏差、与诊室测量相比改善短期和长期血压的可重复性、在患者选择过程中消除“白大衣”效应以及能够评估每日一次长效治疗对日间和夜间血压的影响。本文提供了动态血压监测在临床试验中的效用概述，并列举了使用新型肾素 - 血管紧张素系统阻滞剂近期研究数据的具体实例。
