云南红豆杉树皮中重排紫杉烷类化合物。

Rearranged taxanes from the bark of Taxus yunnanensis.

作者信息

Li S H, Zhang H J, Yao P, Sun H D, Fong H H

机构信息

Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2000 Nov;63(11):1488-91. doi: 10.1021/np000118t.

DOI:10.1021/np000118t

PMID:11087589

Abstract

Five new 11(15-->1)-abeo-taxane diterpenoids, taxuyunnanines K-O (1-5), were isolated from an ethanol extract of the bark of Taxus yunnanensis, and their structures were determined using MS and NMR techniques. Compounds 1/2 and 4/5 are rearranged taxane diterpenoids possessing an opened oxetane ring moiety at C4(20). Compounds 4/5 are rearranged taxoids lacking an oxygenated functionality at C-4.

摘要

从云南红豆杉树皮的乙醇提取物中分离出5种新的11(15→1)-去甲紫杉烷二萜类化合物，即云南紫杉碱K - O（1 - 5），并采用质谱和核磁共振技术确定了它们的结构。化合物1/2和4/5是重排紫杉烷二萜类化合物，在C4(20)处具有一个开环的氧杂环丁烷环部分。化合物4/5是在C - 4处缺乏氧化官能团的重排紫杉烷类化合物。