紫杉烷类和紫杉烷类化合物——紫杉属的综合化学成分多样性目录。
Taxanes and taxoids of the genus Taxus - A comprehensive inventory of chemical diversity.
机构信息
Institute of Biological Chemistry and M.J. Murdock Metabolomics Laboratory, Washington State University, Pullman, WA, 99164-7411, USA.
Institute of Biological Chemistry and M.J. Murdock Metabolomics Laboratory, Washington State University, Pullman, WA, 99164-7411, USA.
出版信息
Phytochemistry. 2021 Oct;190:112829. doi: 10.1016/j.phytochem.2021.112829. Epub 2021 Jul 27.
Abstract
The pseudoalkaloid diterpene Taxol® (paclitaxel) emerged as a best-selling anti-cancer drug in the mid-1990s. The compound attracted considerable interest because of its unique mechanism to stabilize microtubules, thus reducing dynamicity and ultimately promoting mitotic arrest. Taxol was originally isolated from members of the genus Taxus. Over the last 50 years, close to 600 metabolites with taxane scaffolds were isolated from various Taxus species and their structures reported. The present review article provides an overview of the known chemical diversity of taxanes, with an emphasis on the functionalization of diterpene scaffolds. The implications of the occurrence of chemically diverse taxane metabolites for unraveling Taxol biosynthesis and enabling pathway engineering are discussed as well.
摘要
在 20 世纪 90 年代中期，伪生物碱二萜紫杉醇（紫杉醇）作为一种畅销的抗癌药物问世。这种化合物因其独特的稳定微管的作用机制而引起了极大的兴趣，从而降低了微管的动态性，最终促进了有丝分裂的停滞。紫杉醇最初是从红豆杉属的成员中分离出来的。在过去的 50 年里，从各种紫杉物种中分离出了近 600 种具有 taxane 支架的代谢物，并报道了它们的结构。本文综述了已知的 taxanes 的化学多样性，重点介绍了二萜支架的功能化。还讨论了化学多样性 taxane 代谢物的出现对揭示紫杉醇生物合成和实现途径工程的意义。
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