Sorrentino V, Barone V, Rossi D
DIBIT, Istituto Scientifico San Raffaele, Via Olgettina 58, 20132 Milan, Italy.
Curr Opin Genet Dev. 2000 Dec;10(6):662-7. doi: 10.1016/s0959-437x(00)00139-8.
Intracellular Ca(2+)-release channels (ICRCs) form a superfamily of genes that encompasses two distinct subfamilies: the inositol trisphosphate receptor and the ryanodine receptor genes, which encode the largest ion channels known today. During evolution from nematodes to man, mechanisms of gene duplication and divergence have increased the number of known ICRC genes, which have been gradually co-opted to contribute to the increasing complexity of intracellular Ca(2+) signalling required for regulation of specialised eukaryotic cell activities.
细胞内钙释放通道（ICRCs）构成了一个基因超家族，它包含两个不同的亚家族：肌醇三磷酸受体和兰尼碱受体基因，它们编码了当今已知的最大离子通道。在从线虫到人类的进化过程中，基因复制和分化机制增加了已知ICRC基因的数量，这些基因已逐渐被用于促进调节特殊真核细胞活动所需的细胞内钙信号传导复杂性的增加。
