Durfee T, Feiler H S, Gruissem W
Department of Plant and Microbial Biology, University of California-Berkeley, 94720, USA.
Plant Mol Biol. 2000 Aug;43(5-6):635-42. doi: 10.1023/a:1006426808185.
The mammalian retinoblastoma tumor suppressor protein (pRb) regulates cell division, differentiation and apoptotic pathways in specific cell types. In association with other proteins, pRb acts in part by modulating transcriptional activity. Elements of the pRb regulatory network have been identified in higher plants. Recent findings involving these proteins, which display amino acid sequence homology and biochemical binding properties analogous to their mammalian counterparts, are discussed.
哺乳动物视网膜母细胞瘤肿瘤抑制蛋白（pRb）在特定细胞类型中调节细胞分裂、分化和凋亡途径。与其他蛋白质结合时，pRb部分通过调节转录活性发挥作用。在高等植物中已鉴定出pRb调节网络的元件。本文讨论了涉及这些蛋白质的最新发现，这些蛋白质显示出与哺乳动物对应物类似的氨基酸序列同源性和生化结合特性。
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