Chaubet-Gigot N
Institut de Biologie Moleculaire des Plantes, Centre National de la Recherche Scientifique, Université Louis Pasteur, Strasbourg, France.
Plant Mol Biol. 2000 Aug;43(5-6):659-75. doi: 10.1023/a:1006303100592.
Although the basic mechanisms which control the progression through the cell cycle appear to be conserved in all higher eukaryotes, the unique features of the plant developmental programme must be somehow reflected in a plant-specific regulation of the factors which control cell division. In the past few years, considerable progress has been achieved in identifying the major components of the cell cycle machinery in plants, especially the cyclin-dependent kinases (CDKs) and their regulatory subunits, the cyclins. The question of how these components direct expression of specific genes at specific stages of the cell cycle, and how they are themselves regulated, constitutes a challenge for the present and for the years to come. This review summarizes our current knowledge of a particular class of plant cyclins, the A-type cyclins, which can be further subdivided into three structural groups. The putative functions of these A-type cyclins are discussed in relation to the presence of remarkable motifs in their amino acid sequences, and to their specific transcriptional regulation, protein amount and subcellular localization.
尽管控制细胞周期进程的基本机制在所有高等真核生物中似乎都是保守的，但植物发育程序的独特特征必定会以某种方式反映在对控制细胞分裂的因子的植物特异性调控中。在过去几年里，在确定植物细胞周期机制的主要成分方面取得了相当大的进展，尤其是细胞周期蛋白依赖性激酶（CDKs）及其调节亚基细胞周期蛋白。这些成分如何在细胞周期的特定阶段指导特定基因的表达，以及它们自身如何被调控，这一问题对当前及未来几年构成了挑战。本综述总结了我们目前对一类特定植物细胞周期蛋白，即A 型细胞周期蛋白的认识，这类细胞周期蛋白可进一步细分为三个结构组。文中讨论了这些 A 型细胞周期蛋白的假定功能，涉及它们氨基酸序列中显著基序的存在、特定的转录调控、蛋白量及亚细胞定位。
