Kirkwood T B, Austad S N
Department of Gerontology, University of Newcastle, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK.
Nature. 2000 Nov 9;408(6809):233-8. doi: 10.1038/35041682.
The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence. Such understanding also helps to clarify how the genome shapes the ageing process, thereby aiding the study of the genetic factors that influence longevity and age-associated diseases.
衰老的进化理论解释了衰老为何会发生,为导致衰老的复杂细胞和分子变化背后的机制提供了宝贵的见解。这种理解还有助于阐明基因组如何塑造衰老过程,从而有助于研究影响寿命和与年龄相关疾病的遗传因素。