Finkel T, Holbrook N J
Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Bethesda, Maryland 20892-1622, USA.
Nature. 2000 Nov 9;408(6809):239-47. doi: 10.1038/35041687.
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
生活在有氧环境中需要进化出有效的细胞策略，以检测并清除被称为活性氧的分子氧代谢产物。在此，我们综述相关证据，即氧化剂的适度与过度产生，以及生物体应对氧化应激的能力，与衰老和寿命有着复杂的联系。
