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线粒体呼吸与活性氧信号在细胞衰老和寿命方面的互补作用。

Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity.

作者信息

Barrientos Antoni

机构信息

Departments of Neurology and of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

出版信息

Aging (Albany NY). 2012 Sep;4(9):578-9. doi: 10.18632/aging.100485.

DOI:10.18632/aging.100485
PMID:22983483
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3492222/
Abstract

Although it is widely accepted that mitochondria play fundamental roles in the mechanisms of cellular and organismal aging and lifespan extension, some open questions remain concerning the requirements for aerobic energy production and the effect of the potentially hazardous reactive oxygen species (ROS) byproducts as well as their interplay with nutrition and caloric intake.

摘要

尽管人们普遍认为线粒体在细胞和机体衰老及寿命延长机制中发挥着重要作用，但关于有氧能量产生的需求、潜在有害的活性氧（ROS）副产物的影响以及它们与营养和热量摄入的相互作用，仍存在一些未解决的问题。

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Cell Metab. 2012 Jul 3;16(1):55-67. doi: 10.1016/j.cmet.2012.05.013.
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Replicative and chronological aging in Saccharomyces cerevisiae.酿酒酵母的复制性和时序性衰老。
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Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.通过适应性线粒体 ROS 信号调控 TORC1 对酵母时序寿命的影响。
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Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.线粒体膜脂在酵母时序性衰老中发挥关键作用的潜在机制
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Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.天然存在的线粒体衍生肽是细胞凋亡、胰岛素敏感性和炎症标志物的年龄依赖性调节因子。
Aging (Albany NY). 2016 Apr;8(4):796-809. doi: 10.18632/aging.100943.
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A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.线粒体 CO2-腺苷酸环化酶-cAMP 信号体控制酵母常氧细胞色素 c 氧化酶活性。
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A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology.一种线粒体靶向化合物通过一种将线粒体膜脂质代谢与线粒体氧化还原生物学联系起来的机制延缓酵母衰老。
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Mitochondrial membrane lipidome defines yeast longevity.线粒体膜脂质组决定酵母寿命。
Aging (Albany NY). 2013 Jul;5(7):551-74. doi: 10.18632/aging.100578.
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Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis.巨自噬是一种寿命保障过程，在热量供应受限的按时间顺序老化的酵母中，它能维持线粒体功能并保持细胞脂质稳态。
Aging (Albany NY). 2013 Apr;5(4):234-69. doi: 10.18632/aging.100547.
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Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.卡路里限制可延长酿酒酵母的时序寿命，且与沉默调节蛋白无关。
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