线粒体呼吸与活性氧信号在细胞衰老和寿命方面的互补作用。
Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity.
作者信息
Barrientos Antoni
机构信息
Departments of Neurology and of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
出版信息
Aging (Albany NY). 2012 Sep;4(9):578-9. doi: 10.18632/aging.100485.
Abstract
Although it is widely accepted that mitochondria play fundamental roles in the mechanisms of cellular and organismal aging and lifespan extension, some open questions remain concerning the requirements for aerobic energy production and the effect of the potentially hazardous reactive oxygen species (ROS) byproducts as well as their interplay with nutrition and caloric intake.
摘要
尽管人们普遍认为线粒体在细胞和机体衰老及寿命延长机制中发挥着重要作用，但关于有氧能量产生的需求、潜在有害的活性氧（ROS）副产物的影响以及它们与营养和热量摄入的相互作用，仍存在一些未解决的问题。
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