接种多瘤病毒VP1假衣壳复合物或多瘤病毒的正常和免疫缺陷小鼠体内DNA的持久性和组织分布
Persistence and tissue distribution of DNA in normal and immunodeficient mice inoculated with polyomavirus VP1 pseudocapsid complexes or polyomavirus.
作者信息
Heidari S, Krauzewicz N, Kalantari M, Vlastos A, Griffin B E, Dalianis T
机构信息
Division of Experimental Oncology, Karolinska Institute, Radiumhemmet, SE-171 76 Stockholm, Sweden.
出版信息
J Virol. 2000 Dec;74(24):11963-5. doi: 10.1128/jvi.74.24.11963-11965.2000.
Abstract
Introduction of DNA into normal and immunodeficient mice, alone or in complex with VP1 pseudocapsids, has been compared to DNA transfer by viral infection. Similar to natural infection and in contrast to plasmid alone, VP1 pseudocapsids efficiently introduced DNA, which remained for months in normal mice and possibly longer in B- and T-cell-deficient mice.
摘要
已将单独的DNA或与VP1假衣壳复合的DNA导入正常和免疫缺陷小鼠，并与通过病毒感染进行的DNA转移作了比较。与自然感染相似且与单独的质粒不同，VP1假衣壳能有效地导入DNA，导入的DNA在正常小鼠中可留存数月，在B细胞和T细胞缺陷小鼠中留存的时间可能更长。
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