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来自卡波西肉瘤相关疱疹病毒的K-bZIP蛋白与p53相互作用并抑制其转录活性。

The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.

作者信息

Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J

机构信息

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejeon 305-701, Korea.

出版信息

J Virol. 2000 Dec;74(24):11977-82. doi: 10.1128/jvi.74.24.11977-11982.2000.

DOI:10.1128/jvi.74.24.11977-11982.2000
PMID:11090200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC112483/
Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with the cellular transcription factor p53 directly in vitro and in vivo. This interaction requires the bZIP domain of K-bZIP and the carboxy-terminal region (amino acids 300 to 393) of p53. We also show that K-bZIP represses the transcriptional activity of p53 which is required for apoptosis of the host cell. These results imply that K-bZIP blocks p53-mediated host cell death through its interaction with p53.

摘要

卡波西肉瘤相关疱疹病毒（KSHV）是一种γ疱疹病毒，与卡波西肉瘤的发病机制有关。KSHV编码K-bZIP（开放阅读框K8），一种属于转录因子基本区域-亮氨酸拉链（bZIP）家族的蛋白质。在此我们表明，K-bZIP在体外和体内均直接与细胞转录因子p53相互作用。这种相互作用需要K-bZIP的bZIP结构域和p53的羧基末端区域（氨基酸300至393）。我们还表明，K-bZIP抑制p53的转录活性，而这是宿主细胞凋亡所必需的。这些结果表明，K-bZIP通过与p53相互作用来阻断p53介导的宿主细胞死亡。

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The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.来自卡波西肉瘤相关疱疹病毒的K-bZIP蛋白与p53相互作用并抑制其转录活性。
J Virol. 2000 Dec;74(24):11977-82. doi: 10.1128/jvi.74.24.11977-11982.2000.
2
Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression.卡波西肉瘤相关疱疹病毒K-bZIP是K-Rta的共调节因子：物理相互作用及启动子依赖性转录抑制
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Kaposi's sarcoma-associated herpesvirus K-bZIP protein is necessary for lytic viral gene expression, DNA replication, and virion production in primary effusion lymphoma cell lines.卡波西肉瘤相关疱疹病毒的K-bZIP蛋白对于原发性渗出性淋巴瘤细胞系中的病毒裂解基因表达、DNA复制和病毒粒子产生是必需的。
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The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein.卡波西肉瘤相关疱疹病毒的K-bZIP蛋白通过与CREB结合蛋白相互作用来抑制转化生长因子β信号传导。
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Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesis.卡波西肉瘤相关疱疹病毒/人类疱疹病毒8型K-bZIP调节潜伏相关核蛋白介导的对裂解性起始依赖的DNA合成的抑制作用。
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Kaposi's sarcoma-associated herpesvirus encodes a bZIP protein with homology to BZLF1 of Epstein-Barr virus.卡波西肉瘤相关疱疹病毒编码一种与爱泼斯坦-巴尔病毒的BZLF1具有同源性的bZIP蛋白。
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