Selton D, Andre M, Hascoët J M
Service de Medecine Neonatale, Maternite Regionale Universitaire, 10, rue du Docteur Heydenreich, 54042, Nancy, France.
Clin Neurophysiol. 2000 Dec;111(12):2116-24. doi: 10.1016/s1388-2457(00)00440-5.
Objectives were to precise EEG criteria of normality in very premature infants.
The neonatal electroencephalograms (EEGs) of 17 neurologically normal very premature infants recorded at a conceptional age (CA) of 26-28 weeks have been analyzed. The normality of the infants was defined as normal neonatal cranial ultrasound scans and normal neurological outcome at a minimum postnatal age of 2 years.
All tracings were discontinuous. The bursts (amplitude >/=30 microV) were interhemispherically synchronous and lasted up to 3 min. The interburst intervals lasted up to 46 s. EEG patterns consisted mainly of slow waves (</=3 Hz), with high amplitude (up to 300 microV), occipital predominance and superimposed alpha, beta and theta rhythms. High amplitude theta rhythms predominated on temporal areas, beta rhythms were mainly central, whereas alpha rhythms were central and occipital. Sleep state differentiation began as early as 26 weeks CA. On a given trace, the existence of more mature graphoelements than expected for the CA reflected a normal increasing maturation.
EEG has constant and reproductible patterns in normal very premature infants. This can constitute a basis for the determination of EEG criteria for neurological prognosis in infants of 26-28 weeks CA.
目的是明确极早产儿脑电图正常的标准。
分析了17例神经功能正常的极早产儿在孕龄26 - 28周时记录的新生儿脑电图（EEG）。这些婴儿的正常定义为新生儿头颅超声扫描正常且出生后至少2岁时神经功能结局正常。
所有记录均为间断性。波群（振幅≥30微伏）在两半球间同步，持续时间长达3分钟。波群间间隔持续时间长达46秒。脑电图模式主要由慢波（≤3赫兹）组成，振幅高（高达300微伏），以枕部为主，并叠加有α、β和θ节律。高振幅θ节律在颞区占主导，β节律主要在中央区，而α节律在中央区和枕部。睡眠状态分化早在孕龄26周时就开始了。在给定的记录中，存在比相应孕龄预期更多的成熟图形元素反映了正常的成熟度增加。
正常极早产儿的脑电图具有恒定且可重复的模式。这可为确定孕龄26 - 28周婴儿神经预后的脑电图标准奠定基础。
