Barson F P, Kinsella G J, Ong B, Mathers S E
Neurology Unit, Bethlehem Hospital, 476 Kooyong Road, Caulfield, Victoria 3162, Australia.
J Neurol Sci. 2000 Nov 1;180(1-2):107-13. doi: 10.1016/s0022-510x(00)00413-5.
Different clinical criteria for diagnosing dementia were compared in a sample of 69 patients with motor neurone disease (MND). Participants' performances on a computerised battery of neuropsychological tests were evaluated to assess the usefulness of these tests in predicting dementia in MND. The results indicated that when diagnostic criteria for frontotemporal (FTD) were used as part of a questionnaire method of diagnosing dementia the incidence of dementia in MND was considerably greater than traditional estimates suggest. Through a series of logistic and multiple regressions the results demonstrated that neuropsychological test performance related well to diagnostic classifications of dementia. MND patients with a clinical diagnosis of dementia were likely to demonstrate impaired new learning; poor working memory and planning; slowness in information processing and rigidity in thinking. These features, which are typical of cases of FTD, suggest that the dementia of MND is usefully characterised as a form of FTD. The finding that neuropsychological impairment correlated with behavioural features of dysexecutive impairment in daily living, indicates that the management focus in MND must be broadened to include cognitive/behavioural issues.
在69例运动神经元病（MND）患者样本中，对不同的痴呆诊断临床标准进行了比较。评估了参与者在一组计算机化神经心理测试中的表现，以评估这些测试在预测MND患者痴呆方面的效用。结果表明，当将额颞叶痴呆（FTD）的诊断标准作为痴呆问卷调查方法的一部分时，MND患者中痴呆的发生率远高于传统估计。通过一系列逻辑回归和多元回归分析，结果表明神经心理测试表现与痴呆的诊断分类密切相关。临床诊断为痴呆的MND患者可能表现出新学习能力受损；工作记忆和计划能力差；信息处理缓慢和思维僵化。这些FTD病例的典型特征表明，MND的痴呆可有效地被表征为FTD的一种形式。神经心理损伤与日常生活中执行功能障碍的行为特征相关这一发现表明，MND的管理重点必须扩大到包括认知/行为问题。
